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PD-L1 (SP142)

Alias/Synonym: Programmed Death Ligand 1, Clone SP142

CPT Code: 88360

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
To limit damage to surrounding tissue, normal cells differentiate themselves by expressing a protein signal called PD-L1 (programmed death ligand 1). This PD-L1 signal is a stop sign designed to avoid elimination of normal cells by cytotoxic T cells. T cells detect the PD-L1 signal through a receptor called PD-1 (programmed death receptor 1). Some tumors can also express the PD-L1 signal to mimic normal cells and escape elimination. Anti-PD-1 therapy works by blocking the PD-1/PD-L1 interaction. PD-L1 expression may be associated with patient benefit from anti-PD-1 therapy.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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