PAX-5
Alias/Synonym: B-Cell Transcription Factor
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- Pax genes are a family of developmental control genes that encode nuclear transcription factors and have been implicated in the control of mammalian development. PAX-5 encodes for B-cell specific activator protein (BSAP), which is a B cell specific transcription factor that is expressed in pro B cells, pre-B and mature B cells, and subsequently in all stages of B cell development until the plasma cell stage in which it is downregulated. It is positive in most B cell malignancies, and is very helpful for evaluation of B-cell neoplasms after rituximab therapy which may downregulate CD20 expression. It is usually positive in Reed-Sternberg cells of Hodgkin lymphoma, and may be present in Merkel cell carcinoma and small cell carcinoma.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A