p40

Alias/Synonym: P63 Isoform, Squamous Cell Carcinoma, Basal and Myoepithelial Marker

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

p63 protein is a nuclear transcription factor which is a member of the P53 gene family. p40 is an antibody developed to the N terminal domain of p63 and is the predominant subtype in basal/progenitor cells. p63 suffers from specificity limitations due to reactivity in a subset of lung adenocarcinomas (ADC). In contrast, p40 is selectively expressed in lung squamous cell carcinoma (SqCC), offering an opportunity for improved specificity. p40 antibody (M) [BC28] recognizes an epitope unique to p40, which may result in diminished reactivity in lung ADC and increased specificity. Studies have supported routine use of p40 as an alternative for p63, including its use as a basal cell marker in prostate and myoepithelial marker in breast. In contrast to the rabbit polyclonal p40, p40 [BC28] does not stain macrophages.

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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