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p120

Alias/Synonym: Junctional Plaque Protein, Catenin

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 Catenin corresponds with loss of cytoplasmic localization of E-cadherin. In lobular carcinoma, loss of surface E-cadherin, with which p120 catenin associates, leads to abnormal accumulation of p120 catenin in the cytoplasm, aiding in distinction of lobular vs. ductal neoplasms.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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