NSE
Alias/Synonym: Neuron Specific Enolase, Neuroendocrine Tumors
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- Enolase is a glycolytic enzyme catalyzing the reaction pathway between 2-phosphoglycerate and phosphoenol pyruvate. In mammals, enolase molecules are dimers composed of three distinct subunits (α, β and γ). The alpha-alpha dimer (R enolase) is the target for Neuron Specific Enolase, and is found in neural tissue, neuroendocrine cells and their tumors. However, the antibody also cross-reacts with the alpha-gamma heterodimer, which is present in a wide range of non-neuroendocrine cells, including smooth muscle, myoepithelial cells, platelets, lymphocytes, cells of the loop of enle, some carcinomas of the kidney, breast and ovary, and in seminomas.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A