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Alias/Synonym: Neuron Specific Enolase, Neuroendocrine Tumors

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Enolase is a glycolytic enzyme catalyzing the reaction pathway between 2-phosphoglycerate and phosphoenol pyruvate. In mammals, enolase molecules are dimers composed of three distinct subunits (α, β and γ). The alpha-alpha dimer (R enolase) is the target for Neuron Specific Enolase, and is found in neural tissue, neuroendocrine cells and their tumors. However, the antibody also cross-reacts with the alpha-gamma heterodimer, which is present in a wide range of non-neuroendocrine cells, including smooth muscle, myoepithelial cells, platelets, lymphocytes, cells of the loop of enle, some carcinomas of the kidney, breast and ovary, and in seminomas.
Turnaround Time:
1 day(s)
Reference Ranges: