Lymphoma FISH Panel
Alias/Synonym: NHL , Non-Hodgkin Lymphoma
CPT Code: 88377x4
- Includes:
- IGH/CCND1, IGH/BCL2, MYC, BCL-6
- Specimen Type, Preferred:
- Bone marrow aspirate
- Specimen Type, Alternate:
- Peripheral blood
- Formalin fixed paraffin embedded tissue
- Sample Quantity, Preferred:
- 2-3 mL aspirate
- 4 slides
- 1 block
- Sample Quantity, Minimum:
- >0.5 mL
- Transport Container:
- Green top (Sodium Heparin) tube
- Lavender top (EDTA) tube
- Unstained slides
- Paraffin block
- Transport Temperature:
- Room temperature
- Collection Instructions:
- If bone marrow is dry tap, submit 5-10mL peripheral blood.
- Charged slides should be cut at 4-5 microns thick.
- Specimen Stability:
- Room temperature for tubes: 7 day(s)
- Room temperature for slides or block: indefinite
- Rejection Criteria:
- Frozen
- Clotted
- Clinical Significance:
- Detects the most common recurrent genetic abnormalities in Non-Hodgkin Lymphoma.
- Limitations:
- FISH can only detect aberrations specifically targeted by probe used.
- Turnaround Time:
- 3 day(s)
- Reference Ranges:
- Quantitative analysis : cutoff value %