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Alias/Synonym: Lymphocyte Enhancer-Binding Factor 1-CLL/SLL

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
LEF1 (lymphoid enhancer-binding factor 1) is a transcription factor mediating Wnt/Beta-catenin signaling. Although it is expressed in most CLL/SLL cases, it may be present in a small number of mantle cell lymphomas. It has also been described in some non-hematopoietic tumors.
Turnaround Time:
1 day(s)
Reference Ranges: