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KRAS Mutation Analysis

Alias/Synonym:

CPT Code: 81275, 81276

Includes:
Codons 12, 13, 61, 117, 146
Specimen Type, Preferred:
Bone marrow aspirate
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Peripheral blood
Sample Quantity, Preferred:
2mL aspirate
10 mL peripheral blood
1 Block
Sample Quantity, Minimum:
0.5mL aspirate
5mL peripheral blood
5 unstained slides
Transport Container:
Lavender top (EDTA) tube
Green top (Sodium Heparin) tube
Paraffin block
Unstained slides
Transport Temperature:
Refrigerated for tubes
Room temperature for blocks
Collection Instructions:
If bone marrow is dry tap, submit 5-10mL peripheral blood.
Specimen Stability:
Room temperature: 2 day(s)
Refrigerated: 3 day(s)
Rejection Criteria:
Room temperature or clotted for tubes
Frozen
Clinical Significance:
Detects mutations in exons 2, 3 and 4 (codons 12, 13, 61, 117 and 146) of the KRAS gene.
Limitations:
This test is designed to detect gene mutations only. It is not intended to detect copy number changes or gene rearrangements.
Turnaround Time:
7 - 10 day(s)
Reference Ranges:
Cutoff value % based on assay sensitivity
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