IgG4

Alias/Synonym: Related Sclerosing Disease

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

IgG4 is an immunoglobulin G subclass of antibody. Mouse monoclonal IgG4 [HP6025] is specific for the Fc region of human IgG4. IgG4 can be helpful in the diagnosis of IgG4 related systemic disease (IgG4-RSD). IgG4-RSD, also known as IgG4-related sclerosing disease, can be found in many different organs and presents itself with such symptoms as lymphoplasmacytic infiltration, mass formation, sclerosis, obliterative phlebitis and increased expression of IgG4+ plasma cells as well as a high IgG4+/IgG+ ratio, typically >30% (1-4).

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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