IgG4
Alias/Synonym: Related Sclerosing Disease
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- IgG4 is an immunoglobulin G subclass of antibody. Mouse monoclonal IgG4 [HP6025] is specific for the Fc region of human IgG4. IgG4 can be helpful in the diagnosis of IgG4 related systemic disease (IgG4-RSD). IgG4-RSD, also known as IgG4-related sclerosing disease, can be found in many different organs and presents itself with such symptoms as lymphoplasmacytic infiltration, mass formation, sclerosis, obliterative phlebitis and increased expression of IgG4+ plasma cells as well as a high IgG4+/IgG+ ratio, typically >30% (1-4).
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A