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HMB45

Alias/Synonym: Melanoma-associated Marker, Angiomyolipomas

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
HMB45 (Human Melanoma Black) is a membrane protein required to form melanosomal fibrils, and facilitates maturation of pre-melanosomes. The antibody detects melanosomal glycoprotein gp100, which is present in melanocytes (normal and neoplastic), as well as other neural crest tumors, some carcinomas and some soft tissue tumors.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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