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HHV8

Alias/Synonym: Human Herpes Virus 8 (Kaposi's Sarcoma)

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Human herpesvirus type 8 (HHV-8) is the likely etiological agent of Kaposi's sarcoma (KS). HHV-8 DNA sequences have been found in Kaposi's sarcoma lesions, primary effusion lymphoma, and multicentric Castleman's disease via polymerase chain reaction and in situ hybridization. Latent nuclear antigen (LNA-1, LNA, LANA-1), also known as ORF73, is a 222- or 234 kD protein that is consistently expressed in HHV-8 infected cells. Anti-HHV-8 labels the latent nuclear antigen protein via immunohistochemistry.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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