HHV8
Alias/Synonym: Human Herpes Virus 8 (Kaposi's Sarcoma)
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- Human herpesvirus type 8 (HHV-8) is the likely etiological agent of Kaposi's sarcoma (KS). HHV-8 DNA sequences have been found in Kaposi's sarcoma lesions, primary effusion lymphoma, and multicentric Castleman's disease via polymerase chain reaction and in situ hybridization. Latent nuclear antigen (LNA-1, LNA, LANA-1), also known as ORF73, is a 222- or 234 kD protein that is consistently expressed in HHV-8 infected cells. Anti-HHV-8 labels the latent nuclear antigen protein via immunohistochemistry.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A