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HGAL

Alias/Synonym: Follicular Lymphoma Marker

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Human germinal center–associated lymphoma (HGAL) protein is specifically expressed in the cytoplasm and membrane of germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the interfollicular and paracortical regions in normal tonsils and lymph nodes. This pattern is of use in the diagnosis of germinal center-derived B-cell lymphomas, particularly with morphologic variants. 
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A