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Glypican-3

Alias/Synonym: Heparin Sulphate Proteoglycan; Fetal Liver, Trophoblast, Hepatocellular Carcinoma, Some Germ Cell tumors and Melanoma

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Glypican-3 is an oncofetal protein that is expressed in fetal liver and trophoblast. Increased expression in a hepatic tumor may favor a hepatocellular carcinoma, and positive expression may be seen in germ cell tumors, particularly yolk sac tumor and choriocarcinoma.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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