Pathline Client Update: Hematopathology Services

Factor 13A

Alias/Synonym: Fibrohistiocytic Tumors, Dendritic Interstitial Cells

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Factor XIIIa, also known as fibrinoligase and fibrin-stabilizing factor, is the last enzyme generated in the blood coagulation cascade. It is a Ca2+-dependent transglutaminase or transamidating enzyme which forms intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules resulting in the mechanical stabilization of the fibrin clot and its resistance to proteolysis. Factor XIIIa may also function to stabilize cell surface molecules and membranes. It is normally detected in megakaryocytes, monocytes, dendritic reticulum cells, dermal dendrocyts and fibroblast-like mesenchymal cells. It is useful in the differential diagnosis of fibrohistiocytic lesions.
Turnaround Time:
1 day(s)
Reference Ranges: