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EGFR Mutation Analysis – Cell Free DNA in Plasma

Alias/Synonym: EGFR, cfDNA, Liquid Biopsy, ctDNA, T790M

CPT Code: 81235

Includes:
Specimen Type, Preferred:
Plasma, derived from Peripheral Blood
Specimen Type, Alternate:
Peripheral Blood
Sample Quantity, Preferred:
2mL Plasma
10 mL Peripheral blood
Sample Quantity, Minimum:
2mL Plasma
5mL Peripheral blood
Transport Container:
Plasma – Sterile container
Blood - Lavender top (EDTA) tube
Transport Temperature:
Plasma – Frozen (-20 to -25 C)
Peripheral blood: Refrigerated (2-8 C)
Collection Instructions:
Plasma separated from blood within four hours of blood draw. Blood must have been fixed in K2EDTA Tube
Specimen Stability:
Frozen Plasma – Up to 12 months
Refrigerated blood 0 Up to 48 hrs
Rejection Criteria:
Plasma – Unfrozen
Peripheral blood -
Clotted
Hemolyzed
Clinical Significance:
This test is designed to assess acquired resistance mutations, specifically T790M, to EGFR tyrosine kinase inhibitors in recurrent lung cancer patients.
Limitations:
Turnaround Time:
7 - 10 day(s)
Reference Ranges:
Quantitative analysis : cutoff value %