DOG 1
Alias/Synonym: GIST, Interstitial Cells of Cajal
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- DOG1 (Discovered On Gist-1) is a membranous calcium activated chloride channel. It is usually detected in gastrointestinal interstitial cells of Cajal, acinic cells in salivary glands, pancreatic centroacinar cells, liver cells and epithelium of various sites. DOG1 antibody expression has been reported to be a very sensitive and specific marker for gastrointestinal stromal tumor (GIST) cells. It has also been detected in adenoid cystic carcinoma of the salivary gland, esophageal carcinoma, and chondroblastoma.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A