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CK5/6

Alias/Synonym: Cytokeratin 5 and 6, Squamous and Mesothelial Cells

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Reacts strongly with cytokeratins 5 and 6 and weakly with cytokeratin 4. The antibody does not cross-react with cytokeratins 1, 7, 8, 10, 13, 14, 18 and 19. It labels mesothelioma, and epithelial basal cells in prostate and tonsil. No reactivity with other mesodermally derived tissues, such as muscle and connective tissues, has been observed. The antibody is a useful aid for classification of epithelioid mesotheliomas, and is usually positive in squamous cell carcinoma.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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