Chronic Lymphocytic Leukemia FISH Panel

Alias/Synonym: CLL, Chronic Lymphocytic Leukemia

CPT Code: 88368, 88377x4

Includes:

ATM, 13q14.2, P53, IGH/CCND1, XCE 12

Specimen Type, Preferred:

Bone marrow aspirate

Specimen Type, Alternate:

Peripheral blood

Sample Quantity, Preferred:

2-3 mL

Sample Quantity, Minimum:

>0.5 mL

Transport Container:

Green top (Sodium Heparin) tube

Lavender top (EDTA) tube

Transport Temperature:

Room temperature

Collection Instructions:

If bone marrow is dry tap, submit 5-10mL peripheral blood.

Specimen Stability:

Room temperature: 7 day(s)

Rejection Criteria:

Frozen

Clotted

Clinical Significance:

Detects the most common recurrent genetic abnormalities in Chronic Lymphocytic Leukemia.

Limitations:

FISH can only detect aberrations specifically targeted by probe used.

Turnaround Time:

3 day(s)

Reference Ranges:

Quantitative analysis : cutoff value %

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