CD7
Alias/Synonym: Pan T-cells, Thymocytes, NK Cells
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- The CD7 molecule is a membrane-bound glycoprotein of 40 kD and is the earliest T cell specific antigen to be expressed in lymphocytes. CD7 antigen is also the only early marker to persist throughout differentiation. CD7 binds galectin-1, and is essential for galectin-1-mediated T-cell death. CD7 antigen is reported to be found on the majority of peripheral blood T cells, most natural killer cells and thymocytes. It is used as a marker for T-cell neoplasms, and is a prognostic factor in several different leukemias/lymphomas.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A