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CD7

Alias/Synonym: Pan T-cells, Thymocytes, NK Cells

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
The CD7 molecule is a membrane-bound glycoprotein of 40 kD and is the earliest T cell specific antigen to be expressed in lymphocytes. CD7 antigen is also the only early marker to persist throughout differentiation. CD7 binds galectin-1, and is essential for galectin-1-mediated T-cell death. CD7 antigen is reported to be found on the majority of peripheral blood T cells, most natural killer cells and thymocytes. It is used as a marker for T-cell neoplasms, and is a prognostic factor in several different leukemias/lymphomas.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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