Alias/Synonym: Endothelium, Stem Cells, GIST, Blasts

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
The CD34 antigen is a single chain transmembrane glycoprotein with a molecular weight of 110 kD. The CD34 protein is selectively expressed on human lymphoid and myeloid hemopoietic progenitor cells. It is a marker for hematogones, or increased blasts in the setting of MDS or leukemia. The CD34 antigen is also expressed on vascular endothelium. It is useful in the differential diagnosis of spindle cell neoplasms, positive in vascular tumors as well as DFSP, SFT, spindle cell lipoma, liposarcoma, some GIST, and meningioma. It may assist in the evaluation of possible lymph/vascular space invasion by other tumor types.
Turnaround Time:
1 day(s)
Reference Ranges: