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CD31

Alias/Synonym: Endothelial Cells, Plasma Cells

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
CD31 antigen (Platelet Endothelium Cell Adhesion Molecule or PECAM-1) is a single chain transmembrane glycoprotein expressed on the surface of platelets, monocytes, granulocytes, B cells and at the endothelial intracellular junction. It binds to CD38 and vitronectin, and plays a role in thrombosis, angiogenesis and leukocyte trafficking across the endothelial barrier. It is strongly expressed on endothelial cells, and is useful in the differential diagnosis of spindle cell neoplasms or in the evaluation of possible lymph/vascular space invasion. It may rarely be expressed on hematolymphoid neoplasms or carcinomas, and should be used in the context of a panel when evaluating an undifferentiated neoplasm.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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