Alias/Synonym: Pan T-cells

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
CD3 is a T-cell marker. When it associates with the T-cell receptor on the cell surface, it mediates signal transduction causing T-cell proliferation and cytokine release. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. It is used as a pan-T-cell marker in many hematopoietic neoplasms, although some T-cell neoplasms may show aberrant loss of this marker. It may also used to highlight T-cells in inflammatory states such as celiac disease or lymphocytic colitis.
Turnaround Time:
1 day(s)
Reference Ranges: