CD3
Alias/Synonym: Pan T-cells
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- CD3 is a T-cell marker. When it associates with the T-cell receptor on the cell surface, it mediates signal transduction causing T-cell proliferation and cytokine release. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. It is used as a pan-T-cell marker in many hematopoietic neoplasms, although some T-cell neoplasms may show aberrant loss of this marker. It may also used to highlight T-cells in inflammatory states such as celiac disease or lymphocytic colitis.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A