CD23
Alias/Synonym: B-Cell Subset, CLL/SLL
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- The CD23 molecule is the low affinity IgE receptor found on B cells. It is a membrane glycoprotein of 45 kD and is reported to be found on a sub-population of peripheral blood cells, B lymphocytes and on EBV-transformed B lymphoblastoid cell lines. It is typically expressed in CLL, often in mediastinal large B-cell lymphoma,, sometimes in follicular lymphoma, rarely in marginal zone and LPL, and is negative in mantle cell lymphoma. Expression of CD23 antigen has been reported on monocytes and dendritic cells, and is useful, along with CD21 for identifying the meshwork of germinal centers. It is also a marker of dendritic cell tumors.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A