CD20
Alias/Synonym: Pan B-cell Antigen
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- The CD20 antigen is a non-glycosylated phosphoprotein of approximately 33kD which is expressed on normal and malignant human B cells and is thought to act as a receptor during B cell activation and differentiation.CD20 antigen has been reported to be expressed on normal B cells from peripheral blood, lymph node, spleen, tonsil, and bone marrow. It is expressed in the large majority of B-cell neoplasms, and is also expressed in the L&H cells of nodular LP Hodgkin lymphoma. Aberrant loss of CD20 expression may be seen after treatment with Rituxan (rituximab).
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A