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CD20

Alias/Synonym: Pan B-cell Antigen

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
The CD20 antigen is a non-glycosylated phosphoprotein of approximately 33kD which is expressed on normal and malignant human B cells and is thought to act as a receptor during B cell activation and differentiation.CD20 antigen has been reported to be expressed on normal B cells from peripheral blood, lymph node, spleen, tonsil, and bone marrow. It is expressed in the large majority of B-cell neoplasms, and is also expressed in the L&H cells of nodular LP Hodgkin lymphoma. Aberrant loss of CD20 expression may be seen after treatment with Rituxan (rituximab).
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A