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CD15

Alias/Synonym: Epithelial, Myeloid and Reed-Sternberg Cells

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
CD15 antigen, also known as X-hapten or Leu-M1, is reported to be expressed on 90 percent of circulating human granulocytes, 30 to 60 percent of circulating monocytes and is absent from normal lymphocytes. The CD15 antigen is also expressed on Reed Sternberg cells of Hodgkin's disease and some leukemias. It may also be used as part of a panel to differentiate adenocarcinoma (positive in many) from mesothelioma (usually negative).
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A