CD138
Alias/Synonym: Plasma Cell and Epithelial Subset, Syndecan-1
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- CD138, syndecan-1, is a transmembrane proteoglycan with a main cellular expression in stratified and simple epithelia. Within the hemopoietic system, CD138 is mainly confined to late stages of B-cell differentiation. CD138 expression is reduced during malignant transformation of various epithelia, and CD138 is rapidly shed by myeloma cells entering into apoptosis. This antibody is a useful aid for classification of multiple myeloma. Anti-CD138 may also be useful for the sub classification of diffuse large B-cell lymphomas.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A