BCL-6

Alias/Synonym: Follicle Center B-cells

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

BCL-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger transcription factor protein of 95 kD, present in the nucleus. The protein protects germinal center B cells against DNA damage-induced apoptosis during somatic hypermutation and class-switch recombination. BCL-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the BCL-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and BCL-6 rearrangements have also been detected in 33 to 45 percent of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the BCL-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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