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Alias/Synonym: Follicle Center B-cells
CPT Code: 88342
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
Sample Quantity, Minimum:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
No liquid specimens.
BCL-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger transcription factor protein of 95 kD, present in the nucleus. The protein protects germinal center B cells against DNA damage-induced apoptosis during somatic hypermutation and class-switch recombination. BCL-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the BCL-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and BCL-6 rearrangements have also been detected in 33 to 45 percent of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the BCL-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.