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Alias/Synonym: Hairy Cell Leukemia
CPT Code: 88342
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
Sample Quantity, Minimum:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
No liquid specimens.
ANXA1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia. By contrast, B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villous lymphocytes and patients with variant hairy cell leukemia-as defined by current morphologic, phenotypic, and clinical criteria-are ANXA1-negative. Of note, benign T cells, myeloid cells, macrophages, some epithelial cells and some sarcomas may also stain positive for Annexin A1.