PD-L1 (SP142)
Alias/Synonym: Programmed Death Ligand 1, Clone SP142
CPT Code: 88360
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- To limit damage to surrounding tissue, normal cells differentiate themselves by expressing a protein signal called PD-L1 (programmed death ligand 1). This PD-L1 signal is a stop sign designed to avoid elimination of normal cells by cytotoxic T cells. T cells detect the PD-L1 signal through a receptor called PD-1 (programmed death receptor 1). Some tumors can also express the PD-L1 signal to mimic normal cells and escape elimination. Anti-PD-1 therapy works by blocking the PD-1/PD-L1 interaction. PD-L1 expression may be associated with patient benefit from anti-PD-1 therapy.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A