Wilms' Tumor
Alias/Synonym: Desmoplastic SRCT, Mesothelioma, Mullerian Tumors, Wilms' Tumor
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- Wilms' tumor protein (WT1) is a transcription factor that plays a role in development of genitourinary organs. It influences cell proliferation. Normal nuclear expression is typically seen in ovarian surface epithelium, fallopian tube, mesothelium, stromal cells of the female genital tract, testicular non-germinal cells, bone marrow stem cells and some splenic cells. In neoplasms, it is most commonly identified in ovarian or peritoneal serous carcinoma, metanephric adenoma, mesothelioma, and sex cord-stromal tumors. It is also identified in numerous nonepithelial tumors such as Wilms' tumor.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A