Pathline Client Update: Hematopathology Services

Uroplakin III

Alias/Synonym: Urothelial Carcinoma

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Uroplakin III is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. It is highly specific to uroepithelial tumors and may be a useful tool in the discrimination of bladder, renal and prostate cancers. Loss of Uroplakin III expression in bladder cancers has been associated with higher grade, muscle-invasive cancer and lymphovascular invasion.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A