p57

Alias/Synonym: Inhibitor of G1 Cyclin Complex, Molar vs. Non-Molar Gestation

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

p57 (cyclin-dependent kinase inhibitor 1C or Kip2) is a nuclear protein involved in cell cycle regulation. Chromosomal rearrangement or abnormal DNA methylation of the gene has been associated with the Beckwith-Wiedemann syndrome. Only the maternal allele of this gene is expressed. This is useful in the evaluation of potential molar pregnancy, as the cytotrophoblast of complete hydatidiform mole will completely lack p57 expression since it is paternally derived.

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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