Alias/Synonym: Cyclin-Dependent Kinase Inhibitor, CIN/High Grade SIL

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
p16 (CDKN2a/INK4a) is an important tumor-suppressor gene, involved in the p16/cyclin-dependent kinase/retinoblastoma gene pathway of cell cycle control. In high-risk HPV infection (particularly in the uterine cervix and head and neck cancer), the E7 HPV protein can inactivate pRB interfere with the pRB regulatory circuit, leading to overexpression of p16. Overexpression of p16 can be used as a surrogate marker for high-risk HPV infection, although HPV infection is not the sole cause of p16 overexpression. It appears to have prognostic significance of head and neck tumors.
Turnaround Time:
1 day(s)
Reference Ranges: