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OCT2

Alias/Synonym: B-cell Transcription Factor

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Oct-2 is a transcription factor that binds to the immunoglobin gene octamer sites regulating B-cell specific genes. Oct-2 antibody protein expression is seen in germinal center B-cells and is greater in germinal center derived B-cell lymphomas. Studies suggest that morphologic and immunohistochemical studies can distinguish most cases of classic Hodgkin’s lymphoma (CHL) from its imitators. However, the differences in expression of BSAP, OCT-2, BOB.1 and the pan B-cell markers CD20, CD22 and CD79a may aid in distinguishing cases of CHL from nodular lymphocyte predominant Hodgkin’s lymphoma and diffuse large B-cell lymphomas.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A