OCT-3/4

Alias/Synonym: Undifferentiated Pluripotent Cells, Germ Cells

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

OCT3/4 is a nuclear POU-domain octamer binding transcription factor specifically expressed in cells with pluripotent capacity. Oct-3/4 [SEMGC] is a mouse monoclonal antibody that has been reported as a superb nuclear marker of classical seminoma and embryonal carcinoma. Oct-3/4 antibody has excellent sensitivity and specificity for these two tumors and can be effectively used as an aid to screen for these neoplasms when dealing with a metastatic tumor of unknown origin.

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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