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Alias/Synonym: DNA Mismatch Repair Protein, MutS Protein Homolog 6

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. This protein is one of the DNA mismatch repair enzymes. Loss of a DNA mismatch repair protein can lead to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of short repetitive nucleotide sequences (microsatellite instability). These defects in MMR have been related to human carcinogenesis. Loss of MSH-6 expression is often present in MSH-2 mutated tumors, but may be seen in isolation, and may indicate a target for germ line DNA analysis for diagnosis of Lynch syndrome.
Turnaround Time:
1 day(s)
Reference Ranges: