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Alias/Synonym: Melanoma-Associated Marker, Adrenal Cortical Tumors, Mart-1

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Melan A, a product of the MART-1 (Melanoma Antigen Recognized by T cells) gene, is a melanocyte differentiation marker. This antigen is expressed in all normal melanocytes and melanocyte cell lines. The A-103 clone also has cross-reactivity with steroid hormone producing cells of the adrenal cortex, granulosa and theca cells of the ovary and Leydig cells of the testis. This antibody is useful for the characterization of melanocytic neoplasms, as well as other tumors, such as PEComas, clear cell sarcoma, angiomyolipoma, lymphangioleiomyomatosis and pulmonary sugar tumor.
Turnaround Time:
1 day(s)
Reference Ranges: