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HER2

Alias/Synonym: c-erbB-2 Oncoprotein (EP3)

CPT Code: 88360

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
HER-2 (HER-2/neu, c-erbB2 or ERBBS2) is a transmembrane receptor tyrosine kinase. When activated or overexpressed, signaling influences cell proliferation, invasion and differentiation of cells. In human cancers, particularly breast and gastroesophageal cancers, HER-2 is activated through amplification of the gene on chromosome 17, resulting in increased copies of the protein on the cell surface. Although over-expression is an adverse prognostic factor, tumors which overexpress this marker are susceptible to treatment with monoclonal antibodies targeting HER-2, such as Herceptin (trastuzumab) or Tykerb (lapatinib ditosylate).
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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