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Desmin

Alias/Synonym: Striated and Smooth Muscle, Desmoplastic Small Round Cell Tumor

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Desmin reacts with an 18 kD rod piece of the intermediate filament protein desmin (53 kD) in skeletal and most smooth muscle cells. The antibody does not appear to recognize other intermediate filament proteins. Desmin appears to maintain the orientation of actin and myosin filaments, and may also play a role in nuclear transcription. It is detected in most tumors of myogenic origin.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A