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Alias/Synonym: Lymphatic Endothelium, Germ Cells, Mesothelium, Basal Squamous Cells, Smooth Muscle, Podoplanin

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
D2-40 (podoplanin) identifies the ~38 kDa O-linked transmembrane sialoglycoprotein podoplanin, which is expressed in lymphatic endothelium, but not in the blood vessel endothelium. Besides the expression in lymphatic endothelium, podoplanin is also found in a variety of other tissues, including mesothelial cells, reticular cells, follicular dendritic cells, ovarian and testicular germ cells. Results aid in the diagnosis of lymphatic invasion of primary tumors, Kaposi's sarcoma, mesothelioma, and some skin adnexal tumors.
Turnaround Time:
1 day(s)
Reference Ranges: