Cytokeratin, High Molecular Weight Keratin

Alias/Synonym: CK HMV (34BE12), CK903

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
NCL-CK34BE12 (also called CK903 or high molecular weight cytokeratin) reacts with human cytokeratin intermediate filament proteins 1, 5, 10 and 14. The antibody is reported to react with squamous epithelium and sweat ducts in normal skin, some pneumocytes, bronchial epithelium and mesothelium in normal lung and bile ducts in normal liver. It also reacts with ductal cells of the normal pancreas, some acinar and ductal cells of normal breast, some follicular epithelia of normal thyroid and some epithelia and mesothelium of the normal small and large bowel. It is useful for highlighting basal cells in prostate tissue, where the presence of basal cells excludes invasive carcinoma.
Turnaround Time:
1 day(s)
Reference Ranges: