Cyclin D1

Alias/Synonym: Cyclin D1/PRAD1, Mantle Cell Lymphoma BCL1

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
This rabbit monoclonal antibody recognizes a protein of 36 kDa, identified as Cyclin D1 antibody (also known as Bcl-1 or PRAD-1). Cyclin D1 antibody is a regulatory subunit of certain protein kinases thought to advance the G1 phase of the cell cycle. Cyclin D1, when used in tandem with CD5, CD10 and CD23 may aid in the diagnosis for mantle cell lymphoma. Studies show that Cyclin D1 is also expressed in hairy cell leukemia, in a subtype of myeloma, and in many types of carcinoma, Spitz nevus and melanoma.
Turnaround Time:
1 day(s)
Reference Ranges: