CDX2

Alias/Synonym: Intestinal Type Epithelium, Pancreas and Biliary Tract

CPT Code: 88342

Includes:

Specimen Type, Preferred:

Formalin fixed paraffin embedded tissue

Specimen Type, Alternate:

Sample Quantity, Preferred:

1 block

2 slides

Sample Quantity, Minimum:

N/A

Transport Container:

Paraffin block

Unstained slides

Transport Temperature:

Room temperature

Collection Instructions:

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.

Specimen Stability:

N/A

Rejection Criteria:

No liquid specimens.

Uncharged slides

Clinical Significance:

Cdx2, a human gene homologous to the Drosophila caudal-type homeobox gene, encodes a transcription factor which is involved in proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is widely expressed in intestinal epithelium from the duodenum to the rectum. Scattered expression has been reported in pancreatic ductules, while no expression has been observed in other normal tissues tested. In the stomach and esophagus, expression occurs in the presence of intestinal metaplasia. Results aid in the classification of both primary and metastatic tumors of the gastrointestinal tract, including carcinoids. Heterogeneous expression can be seen in pulmonary adenocarcinoma, endometrioid adenocarcinoma and non-intestinal type cervical adenocarcinoma.

Limitations:

Turnaround Time:

1 day(s)

Reference Ranges:

N/A

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