Alias/Synonym: Suppressor/Cytotoxic T-cells; Splenic Littoral Cells

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
The CD8 molecule is composed of two chains and has a molecular weight of 32 kD. It is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20 to 35 percent of human peripheral blood lymphocytes. The CD8 antigen is reported to be detected on natural killer cells, 80 percent of thymocytes, on a subpopulation of 30 percent of peripheral blood null cells and 15 to 30 percent of bone marrow cells. It is used in classifying T-cell lymphomas.
Turnaround Time:
1 day(s)
Reference Ranges: