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Alias/Synonym: N-CAM; Neural and Neuroendocrine Markers, NK Cells

CPT Code: 88342

Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
The neural cell adhesion molecules are a family of closely-related cell surface glycoproteins thought to play a role in embryogenesis, development and contact-mediated interactions between neural cells. The CD56 antigen (NCAM) consists of four major isoforms generated by differential splicing of the RNA transcript from a single gene located on chromosome 5. The CD56 antigen is expressed on neurons, astrocytes, Schwann cells, NK cells and a subset of activated T lymphocytes. The antigen is positive in acute and chronic myeloid leukemia, ovarian sex cord-stromal tumors, Wilms' tumor, neuroblastoma, ganglioneuroblastoma, tumors of neuroendocrine origin, many soft tissue tumors, most NK and NK/T-cell lymphomas, myeloma, mesothelioma, and some brain tumors.
Turnaround Time:
1 day(s)
Reference Ranges: