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CD5

Alias/Synonym: Pan T-cells, B-cell Subset, Thymic Carcinoma

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
CD5 antigen is reported to be expressed on 95 percent of thymocytes and 72 percent of peripheral blood lymphocytes.  In lymph nodes, the main reactivity is observed on T cells. CD5 antigen is also expressed by many T cell leukemias, lymphomas, and activated T cells. It is seen in normal B-lymphocytes which produce low affinity antibodies and have not yet undergone somatic hypermutation.  CD5 antigen expression is present in most CLL/SLL, mantle cell lymphoma and thymic carcinoma.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A