CD4
Alias/Synonym: Helper/Inducer T-cells, Thymocyte and Monocyte Subsets
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- The CD4 molecule (T4) is a single chain transmembrane glycoprotein that is associated with HLA class II antigen recognition. It defines the helper subset of T-lymphocytes, and is present on monocytic cells. It is the receptor for HIV to enter the cells. Most cases of T-cell lymphoma/leukemia, with some exceptions, express CD4. It is also present in histiocytic sarcoma, LCH, blastic plasmacydoid dendritic cell neoplasm, some cases of AML and some inflammatory conditions.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A