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CD163

Alias/Synonym: Monocytic/Histiocytic Cell Marker

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
CD163 antibody aids in identifying cells of monocyte/macrophage lineage in normal and neoplastic conditions. This antibody reacts with human scavenger receptor cysteine-rich protein CD163 (p155, M130) found on mononuclear phagocytes including human monocytes and macrophages. Compared with the CD68 antibodies, studies have shown that CD163 demonstrated greater specificity as a marker of disorders of monocyte/macrophage origin. However, immunohistochemical evaluation of CD163 expression does not seem to be a sensitive means of determining monocytic differentiation of AMLs or myeloid sarcoma.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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