CD123
Alias/Synonym: Interleukin-3 Receptor
CPT Code: 88342
- Includes:
- Specimen Type, Preferred:
- Formalin fixed paraffin embedded tissue
- Specimen Type, Alternate:
- Sample Quantity, Preferred:
- 1 block
- 2 slides
- Sample Quantity, Minimum:
- N/A
- Transport Container:
- Paraffin block
- Unstained slides
- Transport Temperature:
- Room temperature
- Collection Instructions:
- Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
- Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
- Specimen Stability:
- N/A
- Rejection Criteria:
- No liquid specimens.
- Uncharged slides
- Clinical Significance:
- The CD123 antigen is also known as the alpha subunit of the human interleukin-3 receptor. It is a type I transmembrane glycoprotein and is a member of the cytokine receptor superfamily. CD123 forms a heterodimer with CD131 (the beta subunit of the interleukin-3 receptor) to form the interleukin-3 receptor, where the cytokine specificity is provided by the alpha subunit and the signal transduction function is provided by the beta subunit. The interleukin-3 receptor is reported to be expressed on monocytes, neutrophils, basophils, eosinophils, megakaryocytes, proliferation and differentiation of these cells. It is identified on the CD4+/CD56+ lineage neoplasm (blastic NK-cell lymphoma). Outside the hematopoietic system CD123 is reported to be expressed in Leydig cells of the testis, some endothelial cells, and cells of the placenta and brain.
- Limitations:
- Turnaround Time:
- 1 day(s)
- Reference Ranges:
- N/A