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Calretinin

Alias/Synonym: Calcium-Binding Protein, Mesothelial Cells, Sex Cord Stromal Tumors, Adrenal Cortical Tumor

CPT Code: 88342

Includes:
Specimen Type, Preferred:
Formalin fixed paraffin embedded tissue
Specimen Type, Alternate:
Sample Quantity, Preferred:
1 block
2 slides
Sample Quantity, Minimum:
N/A
Transport Container:
Paraffin block
Unstained slides
Transport Temperature:
Room temperature
Collection Instructions:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Slides should be positively charged and cut at 3-4 microns for each stain/antibody ordered.
Specimen Stability:
N/A
Rejection Criteria:
No liquid specimens.
Uncharged slides
Clinical Significance:
Calretinin is a calcium-binding protein of 29 kD that is a member of the family of so-called EF-hand proteins that also includes S-100 proteins. Calretinin is reported to be abundantly expressed in neurons. Outside the nervous system, calretinin is reported to be expressed in a range of cell types including mesothelial cells, steroid producing cell, (e.g. adrenal cortical cells, Leydig cells, ovarian theca internal cells as well as Sertoli cells, some neuroendocrine cells, eccrine sweat glands) and other cell types. Most commonly used in the differential diagnosis of mesothelial proliferations, adrenal tumors, and ovarian sex-cord stromal tumors.
Limitations:
Turnaround Time:
1 day(s)
Reference Ranges:
N/A
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